Current Stem Cell Applications

• Bone Marrow Failure Disorders

        Amegakaryocytosis

        Aplastic Anemia (Severe)

        Blackfan-Diamond Anemia

        Congenital Cytopenia*

        Congenital Dyserythropoietic Anemia

        Dyskeratosis Congenita

        Fanconi Anemia

        Paroxysmal Nocturnal Hemoglobinuria (PNH)

        Pure Red Cell Aplasia

• Hemoblobinopathies

        Beta Thalassemia Major

        Sickle Cell Disease

• Histiocytic Disorders

        Familial Erythrophagocytic Lymphohistiocytosis

        Hemophagocytosis

        Langerhans' Cell Histiocytosis (Histiocytosis X)

• Inherited Immune System Disorders

        Chronic Granulomatous Disease

        Congenital Neutropenia

        Leukocyte Adhesion Deficiency

        Severe Combined Immunodeficiencies (SCID) including:

        Adenosine Deaminase Deficiency*

        Bare Lymphocyte Syndrome

        Chediak-Higashi Syndrome*

        Kostmann Syndrome

        Omenn Syndrome

        Purine Nucleoside Phosphorylase Deficiency

        Reticular Dysgenesis

        Wiskott-Aldrich Syndrome

        X-Linked Lymphoproliferative Disorder

• Inherited Metabolic Disorders

        Adrenoleukodystrophy

        Fucosidosis

        Gaucher Disease*

        Hunter Syndrome (MPS-II)

        Hurler Syndrome (MPS-IH)

        Krabbe Disease

        Lesch-Nyhan Syndrome

        Mannosidosis*

        Maroteaux-Lamy Syndrome (MPS-VI)

        Metachromatic Leukodystrophy

        Mucolipidosis II (I-cell Disease)*

        Neuronal Ceroid Lipofuscinosis (Batten Disease)*

        Niemann-Pick Disease*

        Sandhoff Disease*

        Sanfilippo Syndrome (MPS-III)

        Scheie Syndrome (MPS-IS)

        Sly Syndrome

        Tay Sachs*

        Wolman Disease

• Leukemias and Lymphomas

        Acute Biphenotypic Leukemia*

        Acute Lymphocytic Leukemia (ALL)

        Acute Myelogenous Leukemia (AML)

        Acute Undifferentiated Leukemia*

        Adult T Cell Leukemia/Lymphoma

        Chronic Lymphocytic Leukemia (CLL)

        Chronic Myelogenous Leukemia (CML)

        Hodgkin's Lymphoma

        Juvenile Chronic Myelogenous Leukemia (JCML)

        Juvenile Myelomonocytic Leukemia (JMML)

        Myeloid/Natural Killer (NK) Cell Precursor Acute Leukemia

        Non-Hodgkin's Lymphoma

        Polymphocytic Leukemia

• Myelodysplastic/Myeloproliferative Disorders

        Acute Myelofibrosis*

        Agnogenic Myeloid Metaplasia (Myelofibrosis)*

        Amyloidosis

        Chronic Myelomonocytic Leukemia (CMML)

        Essential Thrombocythemia*

        Polycythemia Vera*

        Refractory Anemias (RA) including:

        Refractory Anemia with Excess Blasts (RAEB)

        Refractory Anemia with Excess Blasts in Transformation (RAEB-T)

        Refractory Anemia with Ringed Sideroblasts (RARS)

• Plasma Cell Disorders

        Multiple Myeloma

        Plasma Cell Leukemia

        Waldenstrom's Macroglobulinemia

        Other Inherited Disorders

        Cartilage-Hair Hypoplasia

        Congenital Erythropoietic Porphyria (Gunther Disease)

        DiGeorge Syndrome 
        
        Osteopetrosis

• Other Malignancies

        Brain Tumors**

        Ewing Sarcoma*

        Neuroblastoma

        Ovarian Cancer*

        Renal Cell Carcinoma*

        Rhabdomyosarcoma

        Small Cell Lung Cancer*

        Testicular Cancer*

        Thymoma (Thymic Carcinoma)

• Other

        Chronic Active Epstein Barr

        Evans Syndrome

        Multiple Sclerosis*

        Rheumatoid Arthritis*

        Systemic Lupus Erythematosus*

        Thymic Dysplasia

* in clinical trials,  www. clinicaltrials.gov

                 Emerging Stem Cell Applications

                 Diabetes

                 Heart Disease

                 Liver Disease

                 Muscular Dystrophy

                 Parkinson's Disease

                 Spinal cord injury

                 Stroke