New clinical data report significant potential for the use of stem cells derived from the tooth pulp
1. Therapy of multiple fractures of cranium bone
Stem cells of the dental pulp were used in patients with severe cranial injuries or in children with abnormalities of the cranial bones, due to congenital malformation and the results were impressive. In a short period of time the bones were recovered.
2. Therapy of the muscular dystrophy of Duchenne
The muscular dystrophy of Duchenne is the most common inherited disease of the neuromuscular system. Patients of 10- 12 years old result in permanent disability and die due to cardiac and respiratory complications. Scientists have used stem cells from the human dental pulp for the treatment of guinea pigs with muscular dystrophy of Duchenne. After the transplantation a clear improvement in the mobility of the guinea pigs was observed. One of the guinea pigs, that was administered with the greatest amount of stem cells was free of symptoms 25 months after therapy. Systematic and repetitive administration of stem cells seems to have better therapeutic results, in guinea pigs, rather than one local administration. These results are very promising for the use of stem cells derived from dental pulp to the therapy of the neuromuscular system diseases.
3. Stem cells from the dental pulp. A new source of stem cells for angiogenesis in myocardial ischemia
Cell therapy using dental pulp stem cells in order to stimulate angiogenesis in the ischemic myocardium is a very interesting field of regenerative medicine. The development of neovascularization in the area of myocardial infarct, that has been repeatedly been observed in guinea pigs after the administration of mesenchymal stem cells of the pulp, is a new therapeutic approach of the restoration of the myocardium after heart attack.
Where can the stem cells from the deciduous teeth be used?
Nowadays it is generally acceptable that stem cells derived from deciduous teeth can have, in the near future, clinical applications equal to the ones of mesenchymal marrow bone and umbilical cord stem cells.
The diseases which are anticipated to be healed are:
Regeneration of new teeth parts and replacement of periodontal tissues
- Implantation and development of new vital teeth with the use of odontoblasts
- Repair of decayed teeth
- Treatment of periodontal diseases
- Pulp regeneration
Potentaila use in tissue regeneration
- Creation of ligaments and cartilage
- Healing of fractures
- Healing of osteoarthritis
- Use in the jawbone reconstruction as bone grafts
Despite the great potential use of stem cells derived from deciduous teeth in medical applications, these can only be used today in autologous transplantations (from the child donor to the same child receiver). In the future they may be able to be used by other histocompatible members of the family.